“We had one individual who was so happy, he took his shirt off and jumped out of the car,” said Michael Weber, the public health director in Josephine County, Ore.

Another recipient, he said, was a Josephine County Sheriff’s Office employee who had arrived too late for the clinic in Cave Junction but ended up stuck with the others on her way back to Grants Pass.

Most drivers laughed at the offer of a roadside coronavirus vaccine and politely declined, even though Mr. Weber said he had a doctor and an ambulance crew on hand to help oversee the operation. He acknowledged it was not the typical setting for a vaccination.

“It was a strange conversation,” Mr. Weber said. “Imagine yourself stranded on the side of the road in a snowstorm and having someone walk up and say: ‘Hey. Would you like a shot in the arm?’”

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